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deoxyribonuclease gamma (DNase gamma, deoxyribonuclease I-like 3, DNase I homolog protein DHP2, liver & spleen DNase, LS-DNase, LSD, DNASE1L3, DHP2, DNAS1L3)
Function:
1) has DNA hydrolytic activity
2) does not bind to actin
3) cleaves chromatin DNA to nucleosomal units
Cofactor: Ca+2, Mg+2
Inhibition:
- inhibited by Zn+2
Kinetic parameters: Optimum pH is about 7.2
Structure:
- belongs to the DNase I family
Compartment:
- nucleus
- may first pass through the ER membrane before import into the nucleus
Expression: expressed in liver & spleen
General
endodeoxyribonuclease
nuclear protein
Properties
SIZE: MW = 36 kD
entity length = 305 aa
COMPARTMENT: cell nucleus
MOTIF: signal sequence {1-20}
nuclear translocation signal {35-51}
glutamate residue {E100}
histidine residue {H155}
cysteine residue {C194}
MODIFICATION: cysteine residue {C231}
cysteine residue {C231}
MODIFICATION: cysteine residue {C194}
nuclear translocation signal {296-304}
Database Correlations
OMIM 602244
UniProt Q13609
Pfam PF03372
References
UniProt :accession Q13609