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deoxycytidine kinase (DCK)
Function:
- required for phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) & deoxyadenosine (dA)
- phosphorylates nucleoside analogs widely employed as antiviral & chemotherapeutic agents
- phosphorylated upon DNA damage, probably by ATM or ATR
NTP + deoxycytidine NDP + dCMP
Structure:
- homodimer
- belongs to the DCK/DGK family
Compartment: nucleus
General
kinase or ATP-phosphotransferase
Properties
SIZE: entity length = 260 aa
MW = 31 kD
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T3}
Ser phosphorylation site {S8}
Ser phosphorylation site {S11}
Ser phosphorylation site {S15}
ATP-binding site
NAME: ATP-binding site
SITE: 28-35
Ser phosphorylation site {S74}
Database Correlations
OMIM 125450
UniProt P27707
Pfam PF01712
KEGG correlations
ENZYME 2.7.1.74
References
UniProt :accession P27707