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dentin sialophosphoprotein [Contains: Dentin phosphoprotein (Dentin phosphophoryn, DPP); Dentin sialoprotein (DSP)] (DSPP)
Function:
- role in dentinogenesis
- binds Ca+2, facilitates initial mineralization of dentin matrix collagen, regulates size & shape of crystals
Compartment: secreted
Expression:
- expressed in teeth
- synthesized by odontoblast
- transiently expressed by pre-ameloblasts
Pathology:
- defects in DSPP are the cause of dentinogenesis imperfecta 1
General
Ca+2 binding protein
phosphoprotein
secreted protein
sialoglycoprotein
Properties
SIZE: MW = 126 kD
entity length = 1253 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-15}
N-glycosylation site {N41}
N-glycosylation site {N49}
N-glycosylation site {N81}
N-glycosylation site {N130}
N-glycosylation site {N150}
N-glycosylation site {N190}
N-glycosylation site {N191}
N-glycosylation site {N209}
N-glycosylation site {N222}
Ser phosphorylation site {S259}
N-glycosylation site {N275}
N-glycosylation site {N336}
N-glycosylation site {N387}
serine-rich region {439-1253}
MOTIF: serine residue (SEVERAL)
Cell attachment site {488-490}
Database Correlations
OMIM correlations
UniProt Q9NZW4
References
UniProt :accession Q9NZW4