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delta-like protein 1; Drosophila delta homolog 1; delta1; H-delta-1 (DLL1)
similar to Drosophila delta protein
Function:
1) ligand for Notch receptors
2) blocks differentiation of progenitor cells into B-cell lineage
3) promotes differentiation or precursors into T-cell/NK-cell
4) interacts with Notch receptors
5) ubiquitinated by MIB1, MIB2, leading to endocytosis & degradation
Structure:
- contains 1 DSL domain
- contains 8 EGF-like domains
Compartment:
- membrane; single-pass type 1 membrane protein
Expression:
- expressed in heart, pancreas > brain, muscle >> placenta, lung, liver, kidney
General
delta homolog protein
glycoprotein
Properties
SIZE: MW = 78 kD
entity length = 723 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {18-545}
MOTIF: EGF domain (6)
calcium-binding EGF-like domain (2)
cysteine residue {C226}
MODIFICATION: cysteine residue {C237}
cysteine residue {C237}
MODIFICATION: cysteine residue {C226}
transmembrane domain {546-568}
cytoplasmic domain {569-723}
Database Correlations
OMIM 606582
UniProt O00548
PFAM correlations
Entrez Gene 28514
Kegg hsa:28514
References
UniProt :accession O00548