protein delta homolog 1; DLK-1; pG2; contains: fetal antigen 1; FA1 (DLK1, DLK)

Function: - may have a role in neuroendocrine differentiation - precursor for fetal antigen 1 (same as pG2) Structure: - N- & O-glycosylated - monomer - contains 6 EGF-like domains Compartment: - membrane; single-pass type 1 membrane protein Alternative splicing: - named isoforms=2; long, short - additional isoforms seem to exist Expression: - found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex & pancreas & in the beta cells of the islets of Langerhans in the adult pancreas Pathology: - expressed in neuroblastoma, pheochromocytoma & small cell lung carcinoma cell lines Genetics: - preadipocyte factor 1 (PREF1) is also derived from the same gene as DLK & is expressed abundantly in preadipocytes

General

delta homolog protein glycoprotein

Properties

SIZE: entity length = 383 aa MW = 41 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-23} EGF domain {24-55} MOTIF: cysteine residue {C26} MODIFICATION: cysteine residue {C37} cysteine residue {C30} MODIFICATION: cysteine residue {C43} cysteine residue {C37} MODIFICATION: cysteine residue {C26} cysteine residue {C43} MODIFICATION: cysteine residue {C30} cysteine residue {C45} MODIFICATION: cysteine residue {C54} EGF domain {53-86} MOTIF: cysteine residue {C54} MODIFICATION: cysteine residue {C45} cysteine residue {C57} MODIFICATION: cysteine residue {C68} cysteine residue {C63} MODIFICATION: cysteine residue {C74} cysteine residue {C68} MODIFICATION: cysteine residue {C57} cysteine residue {C74} MODIFICATION: cysteine residue {C63} cysteine residue {C76} MODIFICATION: cysteine residue {C85} cysteine residue {C85} MODIFICATION: cysteine residue {C76} EGF domain {88-125} MOTIF: cysteine residue {C92} MODIFICATION: cysteine residue {C103} Ser glycosylation site {S94} cysteine residue {C97} MODIFICATION: cysteine residue {C113} N-glycosylation site {N100} cysteine residue {C103} MODIFICATION: cysteine residue {C92} cysteine residue {C113} MODIFICATION: cysteine residue {C97} cysteine residue {C115} MODIFICATION: cysteine residue {C124} cysteine residue {C124} MODIFICATION: cysteine residue {C115} EGF domain {127-168} MOTIF: cysteine residue {C131} MODIFICATION: cysteine residue {C144} cysteine residue {C138} MODIFICATION: cysteine residue {C156} Thr glycosylation site {T143} cysteine residue {C144} MODIFICATION: cysteine residue {C131} cysteine residue {C156} MODIFICATION: cysteine residue {C138} cysteine residue {C158} MODIFICATION: cysteine residue {C167} Ser glycosylation site {S163} N-glycosylation site {N165} cysteine residue {C167} MODIFICATION: cysteine residue {C158} EGF domain {170-206} MOTIF: N-glycosylation site {N172} cysteine residue {C174} MODIFICATION: cysteine residue {C185} cysteine residue {C179} MODIFICATION: cysteine residue {C194} cysteine residue {C185} MODIFICATION: cysteine residue {C174} cysteine residue {C194} MODIFICATION: cysteine residue {C179} cysteine residue {C196} MODIFICATION: cysteine residue {C205} cysteine residue {C205} MODIFICATION: cysteine residue {C196} EGF domain {208-245} MOTIF: cysteine residue {C212} MODIFICATION: cysteine residue {C223} Ser glycosylation site {S214} cysteine residue {C217} MODIFICATION: cysteine residue {C233} Thr glycosylation site {T222} cysteine residue {C223} MODIFICATION: cysteine residue {C212} cysteine residue {C233} MODIFICATION: cysteine residue {C217} cysteine residue {C235} MODIFICATION: cysteine residue {C244} cysteine residue {C244} MODIFICATION: cysteine residue {C235} Ser glycosylation site {S251} Ser glycosylation site {S260} transmembrane domain {304-327}

Database Correlations

OMIM 176290 UniProt P80370 Entrez Gene 8788 Kegg hsa:8788

References

UniProt :accession P80370