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delta-like protein 4; Drosophila delta homolog 4; delta4 (DLL4)
Function:
- plays a role in the notch signaling pathway
- activates notch-1 & notch-4 (putative)
- ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis & subsequent degradation (putative)
- binds to notch-1 & notch-4 (putative)
- possibly involved in regulation of vascular biology
Structure:
- the delta-Serrate-Lag2 (DSL) domain is required for binding to the notch receptor
- contains 1 DSL domain
- contains 8 EGF-like domains
Compartment:
- membrane; single-pass type 1 membrane protein (probable)
Expression:
- expressed in vascular endothelium
General
delta homolog protein
glycoprotein
Properties
SIZE: entity length = 685 aa
MW = 75 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-26}
N-glycosylation site {N108}
DSL {173-217}
MOTIF: cysteine residue {C175}
MODIFICATION: cysteine residue {C184}
N-glycosylation site {N183}
cysteine residue {C184}
MODIFICATION: cysteine residue {C175}
cysteine residue {C188}
MODIFICATION: cysteine residue {C200}
cysteine residue {C200}
MODIFICATION: cysteine residue {C188}
N-glycosylation site {N205}
cysteine residue {C208}
MODIFICATION: cysteine residue {C217}
cysteine residue {C217}
MODIFICATION: cysteine residue {C208}
EGF domain {218-251}
MOTIF: cysteine residue {C222}
MODIFICATION: cysteine residue {C233}
cysteine residue {C226}
MODIFICATION: cysteine residue {C239}
cysteine residue {C233}
MODIFICATION: cysteine residue {C222}
cysteine residue {C239}
MODIFICATION: cysteine residue {C226}
cysteine residue {C241}
MODIFICATION: cysteine residue {C250}
cysteine residue {C250}
MODIFICATION: cysteine residue {C241}
EGF domain {252-282}
MOTIF: cysteine residue {C253}
MODIFICATION: cysteine residue {C264}
cysteine residue {C259}
MODIFICATION: cysteine residue {C270}
cysteine residue {C264}
MODIFICATION: cysteine residue {C253}
cysteine residue {C270}
MODIFICATION: cysteine residue {C259}
cysteine residue {C272}
MODIFICATION: cysteine residue {C281}
cysteine residue {C281}
MODIFICATION: cysteine residue {C272}
EGF domain {284-322}
MOTIF: cysteine residue {C288}
MODIFICATION: cysteine residue {C300}
cysteine residue {C294}
MODIFICATION: cysteine residue {C310}
cysteine residue {C300}
MODIFICATION: cysteine residue {C288}
cysteine residue {C310}
MODIFICATION: cysteine residue {C294}
cysteine residue {C312}
MODIFICATION: cysteine residue {C321}
cysteine residue {C321}
MODIFICATION: cysteine residue {C312}
EGF domain {324-360}
MOTIF: cysteine residue {C328}
MODIFICATION: cysteine residue {C339}
cysteine residue {C333}
MODIFICATION: cysteine residue {C348}
cysteine residue {C339}
MODIFICATION: cysteine residue {C328}
cysteine residue {C348}
MODIFICATION: cysteine residue {C333}
cysteine residue {C350}
MODIFICATION: cysteine residue {C359}
cysteine residue {C359}
MODIFICATION: cysteine residue {C350}
EGF domain {362-400}
MOTIF: cysteine residue {C366}
MODIFICATION: cysteine residue {C377}
cysteine residue {C371}
MODIFICATION: cysteine residue {C388}
cysteine residue {C377}
MODIFICATION: cysteine residue {C366}
cysteine residue {C388}
MODIFICATION: cysteine residue {C371}
cysteine residue {C390}
MODIFICATION: cysteine residue {C399}
N-glycosylation site {N393}
cysteine residue {C399}
MODIFICATION: cysteine residue {C390}
EGF domain {402-438}
MOTIF: cysteine residue {C406}
MODIFICATION: cysteine residue {C417}
cysteine residue {C411}
MODIFICATION: cysteine residue {C426}
cysteine residue {C417}
MODIFICATION: cysteine residue {C406}
cysteine residue {C426}
MODIFICATION: cysteine residue {C411}
cysteine residue {C428}
MODIFICATION: cysteine residue {C437}
cysteine residue {C437}
MODIFICATION: cysteine residue {C428}
EGF domain {440-476}
MOTIF: cysteine residue {C444}
MODIFICATION: cysteine residue {C455}
cysteine residue {C449}
MODIFICATION: cysteine residue {C464}
cysteine residue {C455}
MODIFICATION: cysteine residue {C444}
cysteine residue {C464}
MODIFICATION: cysteine residue {C449}
cysteine residue {C466}
MODIFICATION: cysteine residue {C475}
cysteine residue {C475}
MODIFICATION: cysteine residue {C466}
EGF domain {480-518}
MOTIF: cysteine residue {C484}
MODIFICATION: cysteine residue {C495}
cysteine residue {C489}
MODIFICATION: cysteine residue {C506}
cysteine residue {C495}
MODIFICATION: cysteine residue {C484}
cysteine residue {C506}
MODIFICATION: cysteine residue {C489}
cysteine residue {C508}
MODIFICATION: cysteine residue {C517}
cysteine residue {C517}
MODIFICATION: cysteine residue {C508}
transmembrane domain {530-550}
Database Correlations
OMIM 605185
UniProt Q9NR61
PFAM correlations
Entrez Gene 54567
Kegg hsa:54567
References
UniProt :accession Q9NR61