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delta-6 fatty acid desaturase complex

Function: - the same multienzyme complex catalyzes the desaturation of w9, w7, w6, & w3 unsaturated fatty acids - the delta-6 fatty acid desaturase gives preference to the fatty acid with the most number of double bonds - it is rate limiting in the conversion of alpha-linolenic acid to eicosapentaenoic acid [3,4]

General

dehydrogenase flavoprotein multienzyme complex

Properties

COMPARTMENT: smooth endoplasmic reticulum

References

  1. Textbook of Biochemistry with Clinical Correlations, 3rd ed., TM Devlin (ed), Wiley-Liss, NY 1992 pg 399
  2. Sardesai VM. The essential fatty acids. Nutr Clin Pract. 1992 Aug;7(4):179-86. Review. PMID: 1294887
  3. Davis BC, Kris-Etherton PM. Achieving optimal essential fatty acid status in vegetarians: current knowledge & practical implications. Am J Clin Nutr. 2003 Sep;78(3 Suppl):640S-646S. Review. PMID: 12936959
  4. James MJ, Ursin VM, Cleland LG. Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids. Am J Clin Nutr. 2003 May;77(5):1140-5. PMID: 12716664

Components

cytochrome b5 (CYB5A, CYB5) NADH cytochrome b5 reductase; NADH-methemoglobin reductase stearoyl-CoA desaturase; fatty acid desaturase; delta(9)-desaturase (SCD, SCD1)