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Delta & Notch-like epidermal growth factor-related receptor (DNER, BET, UNQ262/PRO299)
Function:
1) activator of the NOTCH1 pathway
2) mediates neuron-glia interaction during astrocytogenesis (putative)
3) interacts with AP1G1, NOTCH1
Structure:
- contains 10 EGF-like domains contains 1 follistatin-like domain
Compartment:
- cell membrane
- present on the membrane of dendrites & cell bodies
- excluded from axonal membrane
- found in early endosomes in the somatodendritic region
Expression:
- expressed in brain, spinal cord, adrenal gland
General
cell surface receptor
glycoprotein
Properties
SIZE: MW = 78 kD
entity length = 737 aa
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-34}
interaction with NOTCH1 {44-133}
MOTIF: EGF domain {44-92}
cysteine residue {C48}
MODIFICATION: cysteine residue {C59}
cysteine residue {C53}
MODIFICATION: cysteine residue {C80}
cysteine residue {C59}
MODIFICATION: cysteine residue {C48}
cysteine residue {C80}
MODIFICATION: cysteine residue {C53}
cysteine residue {C82}
MODIFICATION: cysteine residue {C91}
cysteine residue {C91}
MODIFICATION: cysteine residue {C82}
EGF domain {94-133}
cysteine residue {C98}
MODIFICATION: cysteine residue {C108}
cysteine residue {C103}
MODIFICATION: cysteine residue {C121}
cysteine residue {C108}
MODIFICATION: cysteine residue {C98}
cysteine residue {C121}
MODIFICATION: cysteine residue {C103}
cysteine residue {C123}
MODIFICATION: cysteine residue {C132}
cysteine residue {C132}
MODIFICATION: cysteine residue {C123}
N-glycosylation site {N223}
EGF domain {309-348}
MOTIF: cysteine residue {C319}
MODIFICATION: cysteine residue {C336}
cysteine residue {C336}
MODIFICATION: cysteine residue {C319}
cysteine residue {C338}
MODIFICATION: cysteine residue {C347}
cysteine residue {C347}
MODIFICATION: cysteine residue {C338}
EGF domain {349-390}
MOTIF: cysteine residue {C353}
MODIFICATION: cysteine residue {C364}
cysteine residue {C358}
MODIFICATION: cysteine residue {C378}
cysteine residue {C364}
MODIFICATION: cysteine residue {C353}
cysteine residue {C378}
MODIFICATION: cysteine residue {C358}
cysteine residue {C380}
MODIFICATION: cysteine residue {C389}
cysteine residue {C389}
MODIFICATION: cysteine residue {C380}
EGF domain {392-428}
MOTIF: cysteine residue {C396}
MODIFICATION: cysteine residue {C407}
cysteine residue {C401}
MODIFICATION: cysteine residue {C416}
cysteine residue {C407}
MODIFICATION: cysteine residue {C396}
cysteine residue {C416}
MODIFICATION: cysteine residue {C401}
cysteine residue {C418}
MODIFICATION: cysteine residue {C427}
cysteine residue {C427}
MODIFICATION: cysteine residue {C418}
EGF domain {430-466}
MOTIF: cysteine residue {C434}
MODIFICATION: cysteine residue {C445}
cysteine residue {C439}
MODIFICATION: cysteine residue {C454}
cysteine residue {C445}
MODIFICATION: cysteine residue {C434}
cysteine residue {C454}
MODIFICATION: cysteine residue {C439}
cysteine residue {C456}
MODIFICATION: cysteine residue {C465}
cysteine residue {C465}
MODIFICATION: cysteine residue {C456}
EGF domain {468-503}
MOTIF: cysteine residue {C472}
MODIFICATION: cysteine residue {C482}
cysteine residue {C477}
MODIFICATION: cysteine residue {C491}
cysteine residue {C482}
MODIFICATION: cysteine residue {C472}
cysteine residue {C491}
MODIFICATION: cysteine residue {C477}
cysteine residue {C493}
MODIFICATION: cysteine residue {C502}
cysteine residue {C502}
MODIFICATION: cysteine residue {C493}
EGF domain {505-541}
MOTIF: cysteine residue {C509}
MODIFICATION: cysteine residue {C520}
cysteine residue {C514}
MODIFICATION: cysteine residue {C529}
cysteine residue {C520}
MODIFICATION: cysteine residue {C509}
cysteine residue {C529}
MODIFICATION: cysteine residue {C514}
cysteine residue {C531}
MODIFICATION: cysteine residue {C540}
cysteine residue {C540}
MODIFICATION: cysteine residue {C531}
EGF domain {543-579}
MOTIF: Follistatin-like {546-568}
cysteine residue {C547}
MODIFICATION: cysteine residue {C558}
cysteine residue {C552}
MODIFICATION: cysteine residue {C567}
cysteine residue {C558}
MODIFICATION: cysteine residue {C547}
N-glycosylation site {N564}
cysteine residue {C567}
MODIFICATION: cysteine residue {C552}
cysteine residue {C569}
MODIFICATION: cysteine residue {C578}
cysteine residue {C578}
MODIFICATION: cysteine residue {C569}
EGF domain {581-617}
MOTIF: cysteine residue {C585}
MODIFICATION: cysteine residue {C596}
cysteine residue {C590}
MODIFICATION: cysteine residue {C605}
cysteine residue {C596}
MODIFICATION: cysteine residue {C585}
cysteine residue {C605}
MODIFICATION: cysteine residue {C590}
cysteine residue {C607}
MODIFICATION: cysteine residue {C616}
cysteine residue {C616}
MODIFICATION: cysteine residue {C607}
transmembrane domain {641-661}
somatodendritic targeting {677-680}
Database Correlations
OMIM 607299
UniProt Q8NFT8
Pfam PF00008
References
UniProt :accession Q8NFT8