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defensin-6; defensin, alpha 6 (DEFA6, DEF6)
Function:
- very low antimicrobial activity against Gram-negative & Gram-positive bacteria
- may protect cells against infection with HIV-1
Structure:
- homodimer
- belongs to the alpha-defensin family
Compartment: secreted
Expression:
- found in Paneth cells of intestinal tract
General
defensin
Properties
SIZE: entity length = 100 aa
MW = 11 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-19}
cysteine residue {C72}
MODIFICATION: cysteine residue {C99}
cysteine residue {C74}
MODIFICATION: cysteine residue {C88}
cysteine residue {C78}
MODIFICATION: cysteine residue {C98}
cysteine residue {C88}
MODIFICATION: cysteine residue {C74}
cysteine residue {C98}
MODIFICATION: cysteine residue {C78}
cysteine residue {C99}
MODIFICATION: cysteine residue {C72}
SECRETED-BY: epithelial cell
WITHIN: intestine
Database Correlations
OMIM 600471
UniProt Q01524
PFAM correlations
Entrez Gene 1671
Kegg hsa:1671
References
- UniProt :accession Q01524
- Entrez Gene :accession 1671