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defensin-5; defensin, alpha 5 (DEFA5, DEF5)
Function:
- antimicrobial activity against Gram-negative & Gram-positive bacteria
- defensins are thought to kill microbes by permeabilizing their plasma membrane
Structure:
- homodimer
- belongs to the alpha-defensin family
Compartment: secreted
Expression:
- found in Paneth cells of intestinal tract
General
defensin
Properties
SIZE: entity length = 94 aa
MW = 10 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-19}
cysteine residue {C65}
MODIFICATION: cysteine residue {C93}
cysteine residue {C67}
MODIFICATION: cysteine residue {C82}
cysteine residue {C72}
MODIFICATION: cysteine residue {C92}
cysteine residue {C82}
MODIFICATION: cysteine residue {C67}
cysteine residue {C92}
MODIFICATION: cysteine residue {C72}
cysteine residue {C93}
MODIFICATION: cysteine residue {C65}
SECRETED-BY: epithelial cell
WITHIN: intestine
Database Correlations
OMIM 600472
UniProt Q01523
PFAM correlations
Entrez Gene 1670
Kegg hsa:1670
References
- UniProt :accession Q01523
- Entrez Gene :accession 1670