neutrophil defensin 4; defensin, alpha 4; HNP-4; HP-4 (DEFA4, DEF4)

Function: - antimicrobial activity against Gram-negative bacteria, & to a lesser extent also against Gram-positive bacteria & fungi - protects blood cells against infection with HIV-1 (in vitro) - has corticostatic effect on adrenal cells - inhibits corticotropin (ACTH)-stimulated cortisol secretion - L-type calcium channel agonist at nanomolar concentrations Structure: - homodimer - belongs to the alpha-defensin family Compartment: - found in microbicidal granules of neutrophils - secreted

Properties

SIZE: entity length = 97 aa MW = 11 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-19} cysteine residue {C65} MODIFICATION: cysteine residue {C93} cysteine residue {C67} MODIFICATION: cysteine residue {C82} cysteine residue {C72} MODIFICATION: cysteine residue {C92} cysteine residue {C82} MODIFICATION: cysteine residue {C67} cysteine residue {C92} MODIFICATION: cysteine residue {C72} cysteine residue {C93} MODIFICATION: cysteine residue {C65}

Database Correlations

OMIM 601157 UniProt P12838 PFAM correlations Entrez Gene 1669 Kegg hsa:1669