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neutrophil defensin 3; defensin, alpha 3; HNP-3; HP-3; HP3; contains: neutrophil defensin 2; HNP-2; HP-2; HP2 (DEFA3, DEF3)
Function:
- defensin 2 & defensin 3 have antibiotic, fungicide & antiviral activities
- defensin 2 apparently arises from cleavage of defensin 1 or defensin 3
- antimicrobial activity against Gram-negative & Gram-positive bacteria
- defensins are thought to kill microbes by permeabilizing their plasma membrane
Structure:
- dimer
- belongs to the alpha-defensin family
Compartment: secreted
General
defensin
phosphoprotein
Properties
SIZE: entity length = 94 aa
MW = 10 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-19}
cysteine residue {C66}
MODIFICATION: cysteine residue {C94}
cysteine residue {C68}
MODIFICATION: cysteine residue {C83}
cysteine residue {C73}
MODIFICATION: cysteine residue {C93}
cysteine residue {C83}
MODIFICATION: cysteine residue {C68}
Tyr phosphorylation site {Y85}
cysteine residue {C93}
MODIFICATION: cysteine residue {C73}
cysteine residue {C94}
MODIFICATION: cysteine residue {C66}
Database Correlations
OMIM 604522
UniProt P59666
PFAM correlations
Entrez Gene 1668
Kegg hsa:1668
References
UniProt :accession P59666