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dedicator of cytokinesis protein 9; Cdc42 guanine nucleotide exchange factor zizimin-1 (DOCK9, KIAA1058)
Function:
1) guanine nucleotide-exchange factor (GEF)
2) activates CDC42 by exchanging bound GDP for free GTP
3) overexpression induces filopodia formation
4) interacts preferentially with nucleotide-depleted CDC42
Structure:
- the DHR-2 domain is necessary & sufficient for the GEF activity
- belongs to the DOCK family
- contains 1 DHR-1 domain
- contains 1 DHR-2 domain
- contains 1 PH domain
Compartment: endomembrane system (probable)
Alternative splicing: named isoforms=4
Expression:
- expressed in heart, placenta > kidney, brain, lung, skeletal muscle
Notes:
- 'Zizim' means 'spike' in Hebrew
General
dedicator of cytokinesis protein (DOCK)
Properties
SIZE: entity length = 2069 aa
MW = 236 kD
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S21}
CDC42 interaction {75-135}
PH domain {174-281}
DHR-1 {640-818}
Ser phosphorylation site {S927}
Ser phosphorylation site {S1186}
DHR-2 {1605-2069}
MOTIF: coiled coil {1948-1982}
coiled coil {2034-2067}
Database Correlations
OMIM 607325
UniProt Q9BZ29
PFAM correlations
Entrez Gene 23348
Kegg hsa:23348
References
UniProt :accession Q9BZ29