dedicator of cytokinesis protein 7 (DOCK7, KIAA1771)

Function: 1) guanine nucleotide exchange factor (GEF) for Rac1 & Rac3 - interacts with nucleotide-free RAC1 & RAC3 2) no GEF activity for CDC42 3) required for STMN1 'Ser-15' phosphorylation during axon formation & consequently for neuronal polarization 4) interacts with TSC1 Structure: - the DHR-2 domain mediates GEF activity - belongs to the DOCK family - contains 1 DHR-1 domain - contains 1 DHR-2 domain Compartment: - cell projection, axon. - enriched in the developing axons of hippocampal neurons Alternative splicing: named isoforms=6 Expression: widely expressed

General

dedicator of cytokinesis protein (DOCK) phosphoprotein

Properties

SIZE: MW = 174 kD entity length = 1542 aa COMPARTMENT: cytoplasm MOTIF: DHR-2 {982-1505}

Database Correlations

UniProt Q96N67 PFAM correlations Entrez Gene 85440 Kegg hsa:85440

References

UniProt :accession Q96N67