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dedicator of cytokinesis protein 5 (DOCK5)
Function:
- guanine nucleotide exchange factor (GEF) for Rho & Rac
Structure:
- the DHR-2 domain may mediate some GEF activity
- belongs to the DOCK family
- contains 1 DHR-1 domain
- contains 1 DHR-2 domain
- contains 1 SH3 domain
Compartment: cytoplasm (putative)
Alternative splicing: named isoforms=2
General
dedicator of cytokinesis protein (DOCK)
phosphoprotein
Properties
SIZE: entity length = 1870 aa
MW = 215 kD
COMPARTMENT: cytoplasm
MOTIF: src homology 3 [SH3] domain
SITE: 8-69
Ser phosphorylation site {S365}
DHR-1 {443-627}
DHR-2 {1231-1642}
Ser phosphorylation site {S1756}
Ser phosphorylation site {S1766}
proline-rich region
SITE: 1782-1855
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S1789}
Thr phosphorylation site {T1794}
Ser phosphorylation site {S1834}
Ser phosphorylation site {S1869}
Database Correlations
UniProt Q9H7D0
PFAM correlations
Entrez Gene 80005
Kegg hsa:80005
References
UniProt :accession Q9H7D0