Dedicator of cytokinesis protein 11 (Zizimin-2, activated Cdc42-associated guanine nucleotide exchange factor, ACG, DOCK11, ZIZ2)

Function: - guanine nucleotide-exchange factor (GEF) - activates CDC42 by exchanging bound GDP for free GTP - interacts with CDC42 (putative) - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - DHR-2 domain is necessary for the GEF activity - belongs to the DOCK family - contains 1 DHR-1 (CZH-1) domain - contains 1 DHR-2 (CZH-2) domain - contains 1 PH domain Note: 'Zizim' means 'spike' in Hebrew

General

dedicator of cytokinesis protein (DOCK) guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS) phosphoprotein

Properties

SIZE: entity length = 2073 aa MW = 238 kD COMPARTMENT: cytoplasm MOTIF: activated CDC42 interaction {66-126} Ser phosphorylation site {S158} Ser phosphorylation site {S161} PH domain {165-272} Ser phosphorylation site {S329} DHR-1 {641-879} guanine nucleotide exchange domain NAME: guanine nucleotide exchange domain Ser phosphorylation site {S1240} DHR-2 {1509-2027}

Database Correlations

UniProt Q5JSL3 PFAM correlations

References

UniProt :accession Q5JSL3