Search
Dedicator of cytokinesis protein 10; Zizimin-3 (DOCK10, KIAA0694, ZIZ3)
Function:
- potential guanine nucleotide exchange factor (GEF)
Structure:
- the DHR-2 domain may mediate some GEF activity
- belongs to the DOCK family
- contains 1 DHR-1 domain
- contains 1 DHR-2 domain
- contains 1 PH domain
Alternative splicing: named isoforms=2
Expression: expressed at low level in brain, lung
General
dedicator of cytokinesis protein (DOCK)
phosphoprotein
Properties
SIZE: entity length = 2186 aa
MW = 250 kD
COMPARTMENT: cytoplasm
MOTIF: PH domain {181-290}
MOTIF: Thr phosphorylation site {T200}
DHR-1 {672-850}
Ser phosphorylation site {S1232}
Ser phosphorylation site {S1257}
Ser phosphorylation site {S1292}
Ser phosphorylation site {S1295}
Ser phosphorylation site {S1318}
Thr phosphorylation site {T1406}
Thr phosphorylation site {T1440}
DHR-2 {1690-2150}
Database Correlations
OMIM 611518
UniProt Q96BY6
PFAM correlations
Entrez Gene 55619
Kegg hsa:55619
References
UniProt :accession Q96BY6