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Decorin; bone proteoglycan II; PG-S2; PG40 (DCN SLRR1B)
Function:
- proteoglycan core protein
- binds to type 1 collagen & type 2 collagen, fibronectin & TGF-beta
- may affect the rate of fibrils formation
- attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin
- forms a ternary complex with MFAP2 & ELN
- interacts with DPT (putative)
Structure:
- belongs to the small leucine-rich proteoglycan (SLRP) family, class I subfamily
- contains 12 LRR repeats (leucine-rich repeats)
Compartment:
- secreted, extracellular space, extracellular matrix
Alternative splicing: named isoforms=5; A,B,C,D,E
Expression: TGF-beta stimulates decorin synthesis
Pathology:
- defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD)
General
matrix protein
proteoglycan core protein
Properties
SIZE: entity length = 359 aa
MW = 40 kD
COMPARTMENT: extracellular matrix
MOTIF: signal sequence {1-16}
Ser glycosylation site {S34}
cysteine-rich region {54-67}
MOTIF: cysteine residue {C54}
MODIFICATION: cysteine residue {C60}
cysteine residue {C58}
MODIFICATION: cysteine residue {C67}
cysteine residue {C60}
MODIFICATION: cysteine residue {C54}
cysteine residue {C67}
MODIFICATION: cysteine residue {C58}
leucine-rich repeat
SITE: 73-93
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 94-117
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 118-141
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 142-162
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 163-186
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 187-212
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N211}
leucine-rich repeat
SITE: 213-233
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 234-257
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 258-281
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N262}
leucine-rich repeat
SITE: 282-304
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N303}
leucine-rich repeat
SITE: 305-334
MOTIF: leucine residue (SEVERAL)
cysteine residue {C313}
MODIFICATION: cysteine residue {C346}
leucine-rich repeat
SITE: 335-359
MOTIF: leucine residue (SEVERAL)
cysteine residue {C346}
MODIFICATION: cysteine residue {C313}
Database Correlations
OMIM correlations
MORBIDMAP 125255
UniProt P07585
PFAM correlations
Entrez Gene 1634
Kegg hsa:1634
References
- UniProt :accession P07585
- SeattleSNPs
http://pga.gs.washington.edu/data/dcn/
- Ruoslahti E, Yamaguchi Y.
Proteoglycans as modulators of growth factor activities.
Cell. 1991 Mar 8;64(5):867-9. Review.
PMID: 2001586