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CD55; complement decay accelerating factor (DAF)
Function:
- inhibits attack by complement on autologous cells
- binds to C3bBb & C14b2b2a to accelerate decay of C3 convertases
- receptor for CD97
Compartment: plasma membrane
Expression:
- expressed on all cells in contact with plasma complement proteins
Pathology:
- deficient in red blood cells in patients with paroxysmal nocturnal hemoglobinuria
- receptor for Coxsackie B virus & echovirus
Specific
complement decay accelerating factor-1 (DAF-1)
complement decay accelerating factor-2 (DAF-2)
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glypiated protein
Properties
SIZE: entity length = 381 aa
MW = 41 kD
COMPARTMENT: plasma membrane
CELL-REGION: apical region
CELL: epithelial cell
MOTIF: signal sequence {1-34}
Sushi domain {35-96}
MOTIF: cysteine residue {C36}
MODIFICATION: cysteine residue {C81}
cysteine residue {C65}
MODIFICATION: cysteine residue {C94}
cysteine residue {C81}
MODIFICATION: cysteine residue {C36}
cysteine residue {C94}
MODIFICATION: cysteine residue {C65}
N-glycosylation site {N95}
Sushi domain {96-160}
MOTIF: cysteine residue {C98}
MODIFICATION: cysteine residue {C145}
cysteine residue {C129}
MODIFICATION: cysteine residue {C158}
Ser phosphorylation site {S140}
cysteine residue {C145}
MODIFICATION: cysteine residue {C98}
cysteine residue {C158}
MODIFICATION: cysteine residue {C129}
Sushi domain {161-222}
MOTIF: cysteine residue {C163}
MODIFICATION: cysteine residue {C204}
cysteine residue {C190}
MODIFICATION: cysteine residue {C220}
cysteine residue {C204}
MODIFICATION: cysteine residue {C163}
cysteine residue {C220}
MODIFICATION: cysteine residue {C190}
Sushi domain {223-285}
MOTIF: cysteine residue {C225}
MODIFICATION: cysteine residue {C267}
cysteine residue {C253}
MODIFICATION: cysteine residue {C283}
cysteine residue {C267}
MODIFICATION: cysteine residue {C225}
cysteine residue {C283}
MODIFICATION: cysteine residue {C253}
threonine-rich region {287-356}
MOTIF: threonine residue (SEVERAL)
glycosyl phosphatidylinositol [GPI] membrane anchor {N353}
Database Correlations
OMIM 125240
UniProt P08174
Pfam PF00084
Entrez Gene 1604
Kegg hsa:1604
References
- Bolen JB, Rowley RB, Spana C, Tsygankov AY.
The Src family of tyrosine protein kinases in hemopoietic
signal transduction.
FASEB J. 1992 Dec;6(15):3403-9. Review.
PMID: 1281458
- OMIM :accession 125240
- http://www.pathologyoutlines.com/cdmarkers.html
15 October 2002
- UniProt :accession P08174
- BGMUT; Note: Blood group antigen gene mutation database
http://www.ncbi.nlm.nih.gov/projects/mhc/xslcgi.fcgi?cmd=bgmut/systems_info&system=cromer
- CD55base; Note: CD55 mutation db
http://bioinf.uta.fi/CD55base/
- Wikipedia; Note: Decay-accelerating factor
http://en.wikipedia.org/wiki/Decay_accelerating_factor
- SeattleSNPs
http://pga.gs.washington.edu/data/daf/
- Virus particle exploreR db; Icosahedral capsid structure
http://viperdb.scripps.edu/info_page.php?VDB=1upn