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death-associated transcription factor 1; death-inducer obliterator 1 (DATF1, DIO-1, C20orf158, KIAA0333)
Function:
1) transcription factor (putative)
2) weakly pro-apoptotic when overexpressed
3) tumor suppressor
Compartment:
- cytoplasm, nucleus
- translocates to the nucleus after pro-apoptotic stimuli
Alternative splicing: named isoforms=4
Expression: ubiquitously expressed
Pathology:
- defects in DATF1 may be a cause of myeloid neoplasms
General
phosphoprotein
transcription factor (TF)
zinc finger protein
Properties
SIZE: entity length = 562 aa
COMPARTMENT: cell nucleus
MOTIF: nuclear translocation signal {165-173}
nuclear translocation signal {185-193}
Zinc finger
NAME: Zinc finger
SITE: 268-322
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S523}
Ser phosphorylation site {S809}
Ser phosphorylation site {S1040}
proline-rich region
SITE: 1257-1286
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 1725-2034
MOTIF: proline residue (SEVERAL)
arginine-rich region {2108-2214}
MOTIF: arginine residue (SEVERAL)
Database Correlations
OMIM 604140
UniProt Q9BTC0
PFAM correlations
Entrez Gene 11083
References
- OMIM :accession 604140
- UniProt :accession Q9BTC0