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mitogen-activated protein kinase kinase kinase DAPK2; DAP kinase 2; DAP-kinase-related protein 1; DRP-1 (DAPK2)
Function:
- Ca+2/calmodulin-dependent serine/threonine kinase
- acts as a positive regulator of apoptosis
- autophosphorylation at Ser-318
Structure:
- homodimer
- homodimerization is required for apoptotic function & is inhibited by autophosphorylation at Ser-318
Compartment: cytoplasm
Expression: ubiquitously expressed
General
oligomerizing protein
serine/threonine kinase
Properties
SIZE: MW = 43 kD
entity length = 370 aa
COMPARTMENT: cytoplasm
STATE: active state
MOTIF: kinase domain
SITE: 23-285
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 29-37
ATP-binding site
NAME: ATP-binding site
SITE: 52-52
aspartate residue {D149}
binding site
SITE: 277-344
FOR-BINDING-OF: calmodulin
MOTIF: Ser phosphorylation site {S318}
Database Correlations
UniProt Q9UIK4
Pfam PF00069
ENZYME 2.7.1.37
References
UniProt :accession Q9UIK4