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ATP-dependent RNA helicase DDX17; DEAD box protein 17; RNA-dependent helicase p72; DEAD box protein p72 (DDX17)
Function:
- RNA-dependent ATPase activity
- ATP + H2O = ADP + phosphate
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- belongs to the DEAD box helicase family, DDX5/DBP2 subfamily
- contains 1 helicase ATP-binding domain
- contains 1 helicase C-terminal domain
Compartment: nucleus
Alternative splicing: named isoforms=4
Expression: ubiquitous
General
DEAD box ATP-dependent helicase
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 650 aa
MW = 72 kD
COMPARTMENT: cell nucleus
MOTIF: glycine-rich region {22-25}
Q motif {92-120}
helicase
NAME: helicase
SITE: 123-298
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 136-143
Tyr phosphorylation site {Y200}
DEAD/H box
NAME: DEAD/H box
SITE: 246-249
Helicase C-terminal {326-473}
MOTIF: Thr phosphorylation site {T444}
glycine-rich region {477-484}
Ser phosphorylation site {S593}
Ser phosphorylation site {S595}
Ser phosphorylation site {S597}
proline-rich region
SITE: 639-647
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 608469
UniProt Q92841
PFAM correlations
Entrez Gene 10521
ENZYME 3.6.4.13
References
UniProt :accession Q92841