DCC-interacting protein 13 alpha; Dip13 alpha, adapter protein containing PH domain; PTB domain & leucine zipper motif 1 (APPL1, APPL, DIP13A, KIAA1428)

Function: 1) regulation of cell proliferation a) response to extracellular signals b) mediated by an early endosomal compartment 2) links Rab5 to nuclear signal transduction 3) binds RAB5A leading to recruitment to endosomal membranes & role in cell proliferation 4) binds DCC 5) binds catalytic domain of the inactive form of AKT2 through PID domain 6) binds PIK3CA 7) binds subunits of the NuRD/MeCP1 complex 8) overexpression has proapoptotic effect 9) interacts with OCRL & INPP5B Structure: - the F&H motif, an approximately 12-13 amino-acid sequence centered around Phe & His residues, is essential for binding to OCRL & INPP5B - contains 1 PH domain - contains 1 PID domain Compartment: - early endosomal membrane, peripheral membrane, nucleus - translocation into the nucleus upon release from endosomal membranes following internalization of EGF Expression: - expressed in heart, ovary, pancreas, skeletal muscle

General

membrane protein nuclear protein

Properties

SIZE: MW = 80 kD entity length = 709 aa COMPARTMENT: cell nucleus endosome MOTIF: binding site SITE: 1-428 FOR-BINDING-OF: rab5a proto-oncogene protein MOTIF: coiled coil {215-259} PH domain {277-375} phosphotyrosine interaction domain NAME: phosphotyrosine interaction domain SITE: 496-656 coiled coil {621-673}

Database Correlations

OMIM 604299 UniProt Q9UKG1 Pfam PF00640 Entrez Gene 26060 Kegg hsa:26060

References

UniProt :accession Q9UKG1