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DBH-like monooxygenase protein 1 (monooxygenase X, MOXD1, MOX, UNQ2493/PRO5780)
Function:
- may play role in biosynthesis of norepinephrine
Cofactor: binds 2 copper ions per subunit (putative)
Structure:
- belongs to the copper type II ascorbate-dependent monooxygenase family
- contains 1 DOMON domain
- N-glycosylated (putative)
Compartment: endoplasmic reticulum membrane (putative)
Alternative splicing: named isoforms=2
Expression:
- highly expressed in lung, kidney, brain & spinal cord
- expressed in fetal liver & fetal brain
- induced by replicative senescence (terminal differentiation) in fibroblasts [2]
Genetics:
- gene located on chromosome 6q24, a region linked with exceptional episodic memory in SuperAgers [3]
General
glycoprotein
hydroxylase; monooxygenase
membrane protein
Properties
SIZE: entity length = 613 aa
MW = 70 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-19}
DOMON {35-148}
MOTIF: N-glycosylation site {N114}
tyrosine residue {Y203}
cysteine residue {C205}
MODIFICATION: cysteine residue {C257}
copper [Cu]-binding site
SITE: 235-235
MOTIF: histidine residue (3)
copper [Cu]-binding site
SITE: 236-236
MOTIF: histidine residue (3)
cysteine residue {C242}
MODIFICATION: cysteine residue {C269}
N-glycosylation site {N247}
cysteine residue {C257}
MODIFICATION: cysteine residue {C205}
cysteine residue {C269}
MODIFICATION: cysteine residue {C242}
active site
copper [Cu]-binding site
SITE: 307-307
MOTIF: histidine residue (3)
cysteine residue {C364}
MODIFICATION: cysteine residue {C480}
cysteine residue {C368}
MODIFICATION: cysteine residue {C550}
histidine residue {H389}
copper [Cu]-binding site
SITE: 389-389
MOTIF: histidine residue (3)
copper [Cu]-binding site
SITE: 391-391
MOTIF: histidine residue (3)
cysteine residue {C443}
MODIFICATION: cysteine residue {C465}
copper [Cu]-binding site
SITE: 464-464
MOTIF: histidine residue (3)
cysteine residue {C465}
MODIFICATION: cysteine residue {C443}
N-glycosylation site {N476}
cysteine residue {C480}
MODIFICATION: cysteine residue {C364}
N-glycosylation site {N517}
cysteine residue {C550}
MODIFICATION: cysteine residue {C368}
transmembrane domain {593-613}
Database Correlations
UniProt Q6UVY6
PFAM correlations
References
- UniProt :accession Q6UVY6
- Chambers KJ, Tonkin LA, Chang E et al
Identification and cloning of a sequence homologue of dopamine
beta-hydroxylase.
Gene. 1998 Sep 18;218(1-2):111-20
PMID: 9751809
- Barral S et al.
Common genetic variants on 6q24 associated with exceptional
episodic memory performance in the elderly.
JAMA Neurol 2014 Oct 13
PMID: 25317765
http://archneur.jamanetwork.com/article.aspx?articleid=1915580