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darusentan
Indications:
- treatment-resistant hypertension
- for use in conjunction with other antihypertensives, including a diuretic
Dosage:
- 50-300 mg PO QD
Adverse effects:
- fluid retention (most common, 25%)
Mechanism of action:
- lowers systolic & diastolic pressures
- reduces systolic blood pressure 10-20 mm Hg systolic
- endothelin-receptor antagonist
Interactions
drug adverse effects of antihypertensive agents
General
vasodilator agent
References
- Weber MA et al
A selective endothelin-receptor antagonist to reduce blood
pressure in patients with treatment-resistant hypertension:
a randomised, double-blind, placebo-controlled trial
Lancet. 2009 Sep 11.
PMID: 19748665
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2809%2961500-2/abstract
- Williams B
Resistant hypertension: an unmet treatment need
Lancet. 2009 Sep 11
PMID: 19748666
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)61600-7/fulltext