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DAN domain family member 5 (cerberus-like protein 2, cerl- 2, Gremlin-3, cysteine knot superfamily 1, BMP antagonist 3) (DAND5 CER2 CKTSF1B3 GREM3 SP1)
Function:
- seems to play a role in the correct specification of the left-right axis
- may antagonize NODAL & BMP4 signaling
- cystine knot-containing proteins play important roles during development, organogenesis, tissue growth & differentiation (putative)
Structure:
- belongs to the DAN family
- contains 1 CTCK (C-terminal cystine knot-like) domain
Compartment: secreted (probable)
General
glycoprotein
secreted protein
Properties
SIZE: entity length = 189 aa
MW = 20 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-22}
N-glycosylation site {N38}
C-terminal cystine knot {101-186}
MOTIF: cysteine residue {C101}
MODIFICATION: cysteine residue {C148}
cysteine residue {C115}
MODIFICATION: cysteine residue {C162}
cysteine residue {C125}
MODIFICATION: cysteine residue {C183}
cysteine residue {C129}
MODIFICATION: cysteine residue {C185}
cysteine residue {C148}
MODIFICATION: cysteine residue {C101}
cysteine residue {C162}
MODIFICATION: cysteine residue {C115}
cysteine residue {C183}
MODIFICATION: cysteine residue {C125}
cysteine residue {C185}
MODIFICATION: cysteine residue {C129}
Database Correlations
UniProt Q8N907
Pfam PF03045
References
UniProt :accession Q8N907