Dachshund homolog 2 (Dach2)

Function: - transcription factor - role in regulation of organogenesis - regulates SIX1 & SIX6 - corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter - recruited with SIX6 to the p27Kip1 promoter in embryonal retina - SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 & HDAC3 - may be involved together with PAX3, SIX1, & EYA2 in regulation of myogenesis - in the developing somite, expression of DACH2 & PAX3 is regulated by the overlying ectoderm, & DACH2 & PAX3 positively regulate each other's expression (putative) - probably binds to DNA via its DACHbox-N domain - interacts with SIX6 & EYA2 (putative) Structure: - belongs to the DACH/dachshund family - DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain (putative) Compartment: nucleus (probable) Alternative splicing: named isoforms=3

General

DNA-binding protein transcription factor (TF)

Properties

SIZE: MW = 65 kD entity length = 599 aa COMPARTMENT: cell nucleus MOTIF: glycine-rich region {56-61} DACHbox-N {69-155} alanine-rich region {350-353} MOTIF: alanine residue (SEVERAL) DACHbox-C {453-533} coiled coil {459-554}

Database Correlations

UniProt Q96NX9 Pfam PF02437

References

UniProt :accession Q96NX9