Search
Dachshund homolog 1 (Dach1)
Function:
- regulation of organogenesis
- regulation of SIX1, SIX6, probably SIX5
- direct repression of cyclin dependent kinase inhibitors
- inhibits TGF-beta signaling through interaction with MADH4 & NCOR1
- interact with SIX1, SIX6, EYA3, NCOR1, HDAC3, SIN3A, MADH3, MADH4
Alternative splicing: 4 splice forms
Expression:
- widely expressed
- isoform 2: brain, heart, kidney, liver, leukocytes, spleen
- isoform 3: liver, heart
- isoform 4: spleen
Genetics: gene locus: 13q22
Related
Dachshund homolog 2 (Dach2)
TGF-beta signalling
General
transcription factor (TF)
Properties
SIZE: MW = 79 kD
entity length = 758 aa
COMPARTMENT: cell nucleus
MOTIF: alanine residue {61-68} (7)
glycine residue {74-87} (13)
glycine residue {90-101} (11)
glycine residue {114-121} (7)
serine residue {140-163} (24)
binding site
SITE: 189-384
FOR-BINDING-OF: homeobox protein SIX6
histone deacetylase 3
MOTIF: DACHBOX-N {189-275}
alanine residue {325-333} (9)
alanine residue {467-470} (4)
DACHBOX-C {616-696}
binding site
SITE: 627-706
FOR-BINDING-OF: paired amphipathic helix protein sin3a
coiled coil {630-718}
Database Correlations
OMIM 603803
UniProt Q9UI36
Pfam PF02437
Entrez Gene 1602
References
UniProt :accession Q9UI36