C-type lectin-like domain family 1 (dendritic cell-associated lectin 1, DC-associated lectin-1, DCAL-1, CLECL1, DCAL1)

Function: - may function in mediating immune cell-cell interactions - may act as a T-cell costimulatory molecule, enhancing anti-CD3-induced proliferation - may play a role in the interaction of dendritic cells with T-cells & the cells of the adaptive immune response Structure: contains 1 C-type lectin domain Compartment: cell membrane Expression: - expressed in spleen, lymph node, & tonsil - lower expression in peripheral blood, bone marrow, & colon - no expression detected in thymus - highly expressed in dendritic & B-cells

General

C-type (calcium dependent, carbohydrate-recognition domain) lectin superfamily or C-type lectin domain family glycoprotein membrane protein

Properties

SIZE: entity length = 167 aa MW = 19 kD COMPARTMENT: cellular membrane MOTIF: transmembrane domain {68-88} N-glycosylation site {N109} C-type lectin; atypical {116-167} MOTIF: N-glycosylation site {N140} N-glycosylation site {N149}

Database Correlations

OMIM 607467 UniProt Q8IZS7 Kegg hsa:1603

References

UniProt :accession Q8IZS7