C-type lectin domain family 7 member A (dendritic cell-associated C-type lectin 1, DC-associated C-type lectin 1, dectin-1, beta-glucan receptor, C-type lectin superfamily member 12, CLEC7A, BGR, CLECSF12 DECTIN1 ORFNames=UNQ539/PRO1082)

Function: 1) lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, i.e. cell wall constituents from pathogenic bacteria & fungi 2) necessary for TLR2-mediated inflammatory response & for TLR2-mediated activation of NF-kappa-B 3) enhances cytokine production in macrophages & dendritic cells 4) mediates production of reactive oxygen species in the cell 5) mediates phagocytosis of C.albicans conidia 6) binds T-cells in a way that does not involve their surface glycans 7) role in T-cell activation, stimulates T-cell proliferation 8) isoform 5 interacts with RANBP9 9) phosphorylated on Tyr in response to glucan binding Structure: - contains 1 C-type lectin domain Compartment: - membrane - isoform 5, 6, 7: cytoplasm Alternative splicing: named isoforms=8 Expression: - highly expressed in peripheral blood leukocytes & dendritic cells - detected in spleen, bone marrow, lung, muscle, stomach, placenta - up-regulated during differentiation from monocytes into dendritic cells

General

C-type (calcium dependent, carbohydrate-recognition domain) lectin superfamily or C-type lectin domain family glycoprotein membrane protein phosphoprotein

Properties

SIZE: MW = 28 kD entity length = 247 aa COMPARTMENT: cytoplasm MOTIF: ITAM-like {15-18} MOTIF: Tyr phosphorylation site {Y15} transmembrane domain {45-65} N-glycosylation site {N91} C-type lectin {127-242} MOTIF: cysteine residue {C148} MODIFICATION: cysteine residue {C241} cysteine residue {C220} MODIFICATION: cysteine residue {C233} cysteine residue {C233} MODIFICATION: cysteine residue {C220} cysteine residue {C241} MODIFICATION: cysteine residue {C148}

Database Correlations

OMIM 606264 MORBIDMAP 606264 UniProt Q9BXN2 PFAM correlations

References

UniProt :accession Q9BXN2