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C-type lectin domain family 2 member D (osteoclast inhibitory lectin, lectin-like NK cell receptor, lectin-like transcript 1, LLT-1, CLEC2D, CLAX, LLT1, OCIL)
Function:
- receptor for KLRB1
- protects target cells against NK cell-mediated lysis
- inhibits osteoclast formation
- inhibits bone resorption
- modulates release of interferon-gamma
- binds high molecular weight sulfated glycosaminoglycans
Structure: contains 1 C-type lectin domain
Compartment: cell membrane
Alternative splicing: named isoforms=4
Expression:
- detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus & spleen
Pathology:
- up-regulated by IL-1alpha & prostaglandin E2 in cultured osteogenic sarcoma cells
General
C-type (calcium dependent, carbohydrate-recognition domain) lectin superfamily or C-type lectin domain family
glycoprotein
membrane protein
receptor
Properties
SIZE: entity length = 191 aa
MW = 22 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {39-59}
C-type lectin {82-185}
MOTIF: N-glycosylation site {N95}
cysteine residue {C103}
MODIFICATION: cysteine residue {C184}
cysteine residue {C184}
MODIFICATION: cysteine residue {C103}
Database Correlations
OMIM 605659
UniProt Q9UHP7
Pfam PF00059
References
UniProt :accession Q9UHP7