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C-type lectin domain family 12 member B (macrophage antigen H, CLEC12B)
Function:
- cell surface receptor
- protects target cells against NK cell-mediated lysis
- modulates signaling cascades
- mediates tyrosine phosphorylation of target MAP kinases
- interacts with PTPN6 & PTPN11
Structure:
- homodimer
- contains 1 ITIM motif
- the phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases
- contains 1 C-type lectin domain
Compartment: cell membrane
Alternative splicing: named isoforms=2
Expression:
- detected in colon, heart, kidney, liver, lung, mammary gland, ovary, spleen & testis
General
C-type (calcium dependent, carbohydrate-recognition domain) lectin superfamily or C-type lectin domain family
glycoprotein
membrane protein
phosphoprotein
Properties
SIZE: entity length = 276 aa
MW = 32 kD
COMPARTMENT: cellular membrane
MOTIF: immunoreceptor tyrosine-based inhibitory motif (ITIM) {5-10}
MOTIF: Tyr phosphorylation site {Y7}
transmembrane domain {44-64}
N-glycosylation site {N91}
C-type lectin {150-264}
MOTIF: cysteine residue {C172}
MODIFICATION: cysteine residue {C263}
N-glycosylation site {N176}
N-glycosylation site {N237}
cysteine residue {C242}
MODIFICATION: cysteine residue {C255}
cysteine residue {C255}
MODIFICATION: cysteine residue {C242}
cysteine residue {C263}
MODIFICATION: cysteine residue {C172}
Database Correlations
UniProt Q2HXU8
Pfam PF00059
References
UniProt :accession Q2HXU8