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C-type lectin domain family 12 member A (myeloid inhibitory C-type lectin-like receptor, MICL, C-type lectin-like molecule 1, CLL-1, dendritic cell-associated lectin 2, DCAL-2, CLEC12A, CLL1, DCAL2, MICL)
Function:
- cell surface receptor
- modulates signaling cascades
- mediates tyrosine phosphorylation of target MAP kinases
- interacts with PTPN6 & PTPN11
Structure:
- highly N-glycosylated
- glycosylation varies between cell types
- contains 1 ITIM motif
- phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases
- contains 1 C-type lectin domain
Compartment:
- cell membrane
- ligand binding leads to internalization
Alternative splicing: named isoforms=5
Expression:
- detected in normal myeloid cells & in acute myeloid leukemia cells
- detected in neutrophils, eosinophils, monocytes & dendritic cells
- detected in spleen macrophage-rich red pulp & in lymph node (at protein level)
- detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes & macrophages
Pathology:
- down-regulated in activated leukocytes recruited to a site of inflammation
General
C-type (calcium dependent, carbohydrate-recognition domain) lectin superfamily or C-type lectin domain family
glycoprotein
membrane protein
receptor
Properties
SIZE: entity length = 275 aa
MW = 32 kD
COMPARTMENT: cellular membrane
MOTIF: immunoreceptor tyrosine-based inhibitory motif (ITIM) {15-20}
transmembrane domain {54-74}
N-glycosylation site {N98}
N-glycosylation site {N108}
C-type lectin {150-259}
MOTIF: cysteine residue {C171}
MODIFICATION: cysteine residue {C258}
N-glycosylation site {N175}
cysteine residue {C237}
MODIFICATION: cysteine residue {C250}
cysteine residue {C250}
MODIFICATION: cysteine residue {C237}
cysteine residue {C258}
MODIFICATION: cysteine residue {C171}
Database Correlations
UniProt Q5QGZ9
Pfam PF00059
References
UniProt :accession Q5QGZ9