C-terminal-binding protein 2 (CtBP2)

Function: - corepressor targeting diverse transcription regulators - component of large corepressor complex - role in brown adipose tissue differentiation - isoform 2 - probably acts as a scaffold for specialized synapses - phosphorylated upon DNA damage, probably by ATM or ATR at Thr-179, Ser-181 & Ser-185 - phosphorylation by HIPK2 on Ser-428 induces proteasomal degradation - can form homodimers or heterodimers of CTBP1 & CTBP2 - interacts with HIPK2 & ZNF217 - interacts with PRDM16 - represses white adipose tissue-specific genes expression (putative) - interacts with PNN, NRIP1 & WIZ Structure: - belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family Compartment: nucleus (putative), cell junction, synapse Alternative splicing: named isoforms=2 Expression: - ubiquitous - highest levels in heart, skeletal muscle, pancreas Pathology: - interacts with the C-terminus of adenovirus E1A protein

General

dehydrogenase nuclear protein phosphoprotein

Properties

SIZE: entity length = 445 aa MW = 49 kD COMPARTMENT: cell nucleus MOTIF: binding site SITE: 106-106 FOR-BINDING-OF: NAD cofactor-binding site [186-191] COFACTOR-BOUND: NAD cofactor-binding site [210-210] COFACTOR-BOUND: NAD cofactor-binding site [243-249] COFACTOR-BOUND: NAD cofactor-binding site [270-272] COFACTOR-BOUND: NAD MOTIF: arginine residue {R272} cofactor-binding site [296-296] COFACTOR-BOUND: NAD glutamate residue {E301} cofactor-binding site [321-324] COFACTOR-BOUND: NAD MOTIF: histidine residue {H321} Ser phosphorylation site {S428}

Database Correlations

OMIM 602619 UniProt P56545 PFAM correlations Entrez Gene 1488 Kegg hsa:1488

References

UniProt :accession P56545