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ski proto-oncogene protein (c-ski, ski)
Function:
- transcriptional corepressor
- role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage
- interacts with Smad2, Smad3, & Smad4, but less so with Smad1 & Smad5
- suppresses signaling of GF-beta & bone morphogenetic proteins (BMPs) through binding to Smad proteins
- interacts with HIPK2
- part of a complex with HIPK2 & Smad1/Smad2/Smad3
Structure: belongs to the SKI family
Compartment: nucleus
Related
ski proto-oncogene
General
proto oncogene protein
transcription factor (TF)
Properties
SIZE: entity length = 728 aa
MW = 80 kD
COMPARTMENT: cell nucleus
MOTIF: coiled coil {536-710}
References
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 986
- Takeda M, Mizuide M, Oka M, Watabe T, Inoue H, Suzuki H,
Fujita T, Imamura T, Miyazono K, Miyazawa K.
Interaction with Smad4 is indispensable for suppression of BMP
signaling by c-Ski.
Mol Biol Cell. 2004 Mar;15(3):963-72. Epub 2003 Dec 29.
PMID: 14699069
- UniProt :accession P12755
Databases & Figures
OMIM 164780
UniProt P12755
PFAM correlations
Kegg hsa:6497
TGF-beta/BMP signaling