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proto-oncogene tyrosine-protein kinase ROS; c-ros protein; p53ros; mcf3 tyrosine kinase receptor; c-ros-1 (ROS1)
Function:
- receptor tyrosine kinase for growth or differentiation factor (putative)
Structure:
- belongs to the protein kinase superfamily, Tyr protein kinase family, insulin receptor subfamily
- contains 9 fibronectin F3 modules
- contains 1 protein kinase domain
Compartment: membrane
Pathology:
- chromosomal aberration involving ROS1 is found in glioblastoma multiform (GBM); homozygous deletion in chromosome 6q21 results in expression of a GOPC-ROS1 chimeric protein with constitutive receptor tyrosine kinase activity
Interactions
molecular events
Related
ros proto-oncogene, ros1 proto-oncogene or mcf1 proto-oncogene
General
proto oncogene protein
tyrosine kinase receptor (RTK)
Properties
SIZE: entity length = 2347 aa
MW = 264 kD
COMPARTMENT: cellular membrane
STATE: active state
MOTIF: signal sequence {1-27}
N-glycosylation site {N52}
fibronectin type III domain or F3 module {98-188}
MOTIF: N-glycosylation site {N114}
N-glycosylation site {N123}
fibronectin type III domain or F3 module {194-281}
N-glycosylation site {N324}
N-glycosylation site {N352}
N-glycosylation site {N396}
N-glycosylation site {N471}
fibronectin type III domain or F3 module {558-668}
MOTIF: N-glycosylation site {N607}
N-glycosylation site {N628}
N-glycosylation site {N706}
N-glycosylation site {N714}
N-glycosylation site {N732}
N-glycosylation site {N939}
fibronectin type III domain or F3 module {944-1036}
MOTIF: N-glycosylation site {N961}
N-glycosylation site {N1015}
fibronectin type III domain or F3 module {1041-1147}
MOTIF: N-glycosylation site {N1087}
N-glycosylation site {N1090}
N-glycosylation site {N1095}
N-glycosylation site {N1211}
N-glycosylation site {N1272}
N-glycosylation site {N1330}
fibronectin type III domain or F3 module {1450-1548}
MOTIF: N-glycosylation site {N1458}
N-glycosylation site {N1461}
N-glycosylation site {N1474}
N-glycosylation site {N1499}
fibronectin type III domain or F3 module {1558-1653}
MOTIF: N-glycosylation site {N1565}
fibronectin type III domain or F3 module {1655-1748}
MOTIF: N-glycosylation site {N1669}
N-glycosylation site {N1715}
N-glycosylation site {N1738}
fibronectin type III domain or F3 module {1749-1851}
MOTIF: N-glycosylation site {N1808}
transmembrane domain {1860-1882}
MOTIF: breakpoint {1880-1881}
kinase domain
SITE: 1945-2222
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 1951-1959
ATP-binding site
NAME: ATP-binding site
SITE: 1980-1980
aspartate residue {D2079}
Tyr phosphorylation site {Y2114}
Database Correlations
OMIM 165020
UniProt P08922
PFAM correlations
Kegg hsa:6098
ENZYME 2.7.10.1
References
- UniProt :accession P08922
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 986
- Ponting CP, Phillips C.
DHR domains in syntrophins, neuronal NO synthases and other
intracellular proteins.
Trends Biochem Sci. 1995 Mar;20(3):102-3.
PMID: 7535955
Component-of
molecular complex