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C-myc promoter-binding protein (DENN domain-containing protein 4A, DENND4A, IRLB, MYCPBP)
Function:
- binds to ISRE-like element* of MYC P2 promoter
* interferon-stimulated response element
Structure:
- contains 1 dDENN domain
- contains 1 DENN domain
- contains 2 PPR repeats (pentatricopeptide repeats)
- contains 1 uDENN domain
Compartment: nucleus
Expression:
- ubiquitous
- expressed in bone marrow > peripheral blood lymphocytes > spleen
- expression is growth- & cell cycle-dependent
- highly expressed in fetal liver
- induced by serum in low-passage fibroblasts
Pathology:
- in brain, breast & prostate expression higher in normal cells than in tumor cells
Related
enolase-1, alpha enolase or phosphopyruvate hydratase
General
DNA-binding protein
transcriptional silencer (transcriptional repressor)
Properties
SIZE: MW = 209 kD
entity length = 1863 aa
COMPARTMENT: cell nucleus
MOTIF: uDENN {6-282}
DENN {308-492}
dDENN {558-632}
PPR repeat {783-809}
PPR repeat {811-845}
nuclear translocation signal {917-933}
glutamate-rich region {1183-1189}
MOTIF: glutamate residue (SEVERAL)
Database Correlations
OMIM 600382
UniProt Q7Z401
PFAM correlations
References
UniProt :accession Q7Z401