C-Myc-binding protein; associate of Myc 1; AMY-1 (MYCBP, AMY1)

Function: - may control the transcriptional activity of MYC - stimulates activation of E box-dependent transcription by MYC - binds via its C-terminal region to the N-terminal region of MYC - associates with AKAP1/S-AKAP84 - interacts with MYCBPAP Structure: belongs to the AMY1 family Compartment: - cytoplasm, nucleus, mitochondria - translocates into the nucleus in S phase of the cell cycle upon an increase of MYC expression - found in the mitochondria when associated with AKAP1 Expression: - highly expressed in heart, placenta, pancreas, skeletal muscle & kidney - also expressed at low levels in lung

General

mitochondrial protein nuclear protein transcription factor, not classified

Properties

SIZE: entity length = 103 aa MW = 12 kD COMPARTMENT: mitochondria cytoplasm cell nucleus

Database Correlations

OMIM 606535 UniProt Q99417 Entrez Gene 26292 Kegg hsa:26292

References

UniProt :accession Q99417