C-Maf-inducing protein (c-Mip, Truncated c-Maf inducing protein, Tc-Mip) (CMIP KIAA1694 TCMIP)

Function: - plays a role in T-cell signaling pathway - isoform 2 may play a role in T-helper 2 (Th2) signaling pathway & seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor - interacts with FLNA Structure: contains 1 PH domain Compartment: - nucleus, cytoplasm Alternative splicing: named isoforms=3 Expression: - isoform 1 is expressed in peripheral blood mononuclear cells & kidney - lower expression in brain & liver - expression is down-regulated in activated cells - isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturation & differentiation in thymus & fetal liver - expressed in fetal liver Pathology: - isoform 2 is up-regulated & specifically translocated to the nucleus during minimal change nephrotic syndrome (MCNS) - detected in nuclear & cytoplasmic compartments during MCNS relapse - expressed in cytoplasm only during MCNS remission & absent in normal patients

Properties

SIZE: entity length = 739 aa MW = 83 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: PH domain {20-129}

Database Correlations

UniProt Q8IY22 Kegg hsa:8079

References

UniProt :accession Q8IY22