C-Jun-amino-terminal kinase-interacting protein 3; JIP-3; JNK-interacting protein 3; JNK MAP kinase scaffold protein 3; mitogen-activated protein kinase 8-interacting protein 3; Sunday driver, drosophila homolog of 2 (MAPK8IP3, JIP3, KIAA1066)

Function: - the JNK-interacting protein (JIP) group of scaffold proteins selectively mediate JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module - may function as a regulator of vesicle transport, through interations with the JNK-signaling components & motor proteins (putative) - phosphorylated upon DNA damage, probably by ATM or ATR - forms homo- or heterooligomeric complexes - the central region of MAPK8IP3 a) interacts with the C-terminal of MAPK8IP2 b) does not interact with the C-terminal of MAPK8IP1 - binds specific components of the JNK signaling pathway namely a) MAPK8, MAPK9 & MAPK10 to the N-terminal region b) MAP2K4 & MAP2K7 to the central region c) MAP3K11 to the C-terminal region - binds the TPR motif-containing C-terminal of kinesin light chain, KLC1; pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location (putative) Structure: belongs to the JIP scaffold family Compartment: cytoplasm (putative) Alternative splicing: named isoforms=2

General

c-jun-amino-terminal kinase interacting protein (JNK-interacting protein, JIP, JNK MAP kinase scaffold protein) phosphoprotein

Properties

SIZE: entity length = 1336 aa MW = 147 kD COMPARTMENT: cytoplasm MOTIF: coiled coil {58-177} Thr phosphorylation site {T265} Ser phosphorylation site {S267} Thr phosphorylation site {T275} Thr phosphorylation site {T286} Ser phosphorylation site {S365} coiled coil {440-554} Ser phosphorylation site {S585} Ser phosphorylation site {S676}

Database Correlations

OMIM 605431 UniProt Q9UPT6 Pfam PF09744 Entrez Gene 23162 Kegg hsa:23162

References

UniProt :accession Q9UPT6