C-Jun-amino-terminal kinase-interacting protein 2; JIP-2; JNK-interacting protein 2; Islet-brain-2; IB-2; JNK MAP kinase scaffold protein 2; mitogen-activated protein kinase 8-interacting protein 2 (MAPK8IP2, IB2, JIP2 PRKM8IPL)

Function: - the JNK-interacting protein (JIP) group of scaffold proteins selectively mediate JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module - JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells - may function as a regulator of vesicle transport, through interactions with JNK-signaling components & motor proteins (putative) - forms homo- or heterooligomeric complexes - binds specific components of the JNK signaling pathway namely JNK, MAPKK7 & MLK2, MLK3 & DLK - also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (apoER2) - binds cytoplasmic tails of LRP1 & LRP2 (megalin) - binds the TPR motif-containing C-terminal of kinesin light chain, Klc1; pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location (putative) - interacts with the cytoplasmic domain of APP (putative) Structure: - belongs to the JIP scaffold family - contains 1 PID domain - contains 1 SH3 domain Compartment: - cytoplasm - accumulates in cell surface projections Alternative splicing: named isoforms=4 Expression: - expressed mainly in the brain & pancreas, including insulin-secreting cells - in the nervous system, more abundantly expressed in the cerebellum, pituitary gland, occipital lobe & the amygdala - also expressed in fetal brain - very low levels found in uterus, ovary, prostate, colon, testis, adrenal gland, thyroid gland & salivary gland

Properties

SIZE: entity length = 824 aa MW = 88 kD COMPARTMENT: cytoplasm MOTIF: acidic region {30-36} MOTIF: acidic residue (SEVERAL) acidic region {85-103} MOTIF: acidic residue (SEVERAL) binding site SITE: 110-275 FOR-BINDING-OF: c-jun NH2 terminal kinase, jun kinase (JNK) or stress-activated protein kinase (SAPK) serine-rich region {279-291} MOTIF: serine residue (SEVERAL) proline-rich region SITE: 417-434 MOTIF: proline residue (SEVERAL) acidic region {469-481} MOTIF: acidic residue (SEVERAL) src homology 3 [SH3] domain SITE: 604-665 phosphotyrosine interaction domain NAME: phosphotyrosine interaction domain SITE: 677-813

Database Correlations

OMIM 607755 UniProt Q13387 PFAM correlations Entrez Gene 23542 Kegg hsa:23542

References

UniProt :accession Q13387