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fps proto-oncogene protein or fes proto-oncogene protein

Structure: - the substrate specificity of fps matches the binding preference of its SH2-domain [3] - the recognition motif for the viral oncogene protein p85gag-fes is REEADGV[Y*]AASGGLR [2]

Interactions

molecular events

Related

fps/fes (Fujimani poultry sarcoma/feline sarcoma) proto-oncogene p85 Gag fes oncoprotein

General

fps protein or fes protein membrane protein proto oncogene protein

Properties

COMPARTMENT: cellular membrane MOTIF: membrane region Tyr phosphorylation site kinase domain MOTIF: ATP-binding site NAME: ATP-binding site STATE: active state MISC-INFO: RECOGNITION-MOTIF :SEQUENCE REEADGV[Y*]AASGGLR :REF " - Kemp BE, Pearson RB. Protein kinase recognition sequence motifs. Trends Biochem Sci. 1990 Sep;15(9):342-6. Review. PMID: 2238044"

Database Correlations

OMIM 190030 UniProt P07332

References

  1. Ellis C, Moran M, McCormick F, Pawson T. Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases. Nature. 1990 Jan 25;343(6256):377-81. PMID: 1689011
  2. Kemp BE, Pearson RB. Protein kinase recognition sequence motifs. Trends Biochem Sci. 1990 Sep;15(9):342-6. Review. PMID: 2238044
  3. Pawson T Protein modules and signalling networks Nature 373:573 1995 PMID: 7531822

Component-of

molecular complex