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C elegans AGE-1 gene

Mutations in the C elegans gene AGE-1 reduce Gompertz rate of mortality. The gene encodes a homolog of phosphoinositide-3-kinase.

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Caenorhabditis elegans

General

invertebrate-specific gene

References

  1. Mobbs C, Molecular & biological factros in aging In: Geriatric Medicine: An Evidence-Based Approach, 4th ed, Cassel CK et al (eds), Springer-Verlag, New York, 2003
  2. Johnson TE Increased life span of age-1 mutantsin Caenorhabditis elegans and lower Gompertz rate of aging. Science 1990; 249:908
  3. Morris JZ et al, A phosphatidyl inositol 3-OH kinase family member regulating longevity and dipause in Caenorhabditis elegans. Nature 1966; 382:536