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cyt P450 2C19 gene

Also upregulated by pregnane X receptor. Polymorphic gene. Variant allele frequency in Caucasians 13% [2]

Related

cytochrome P450 2C19 (cytochrome P450 2C17, cytochrome P450 11A, mephenytoin 4-hydroxylase, cytochrome P450 254C, CYP2C19)

General

unclassified gene

Properties

TEMPLATE-FOR: messenger RNA TEMPLATE-FOR: cyt P450 2C19 MOTIF: androstane receptor binding element NAME: androstane receptor binding element glucocorticoid response element NAME: glucocorticoid response element transcriptional start site exon intron transcriptional termination site

References

  1. Chen Y et al, Exp Biol 2002, abstr 156.2
  2. Pirmohamed M & Park BK, Toxicology 192:23-32, 2003