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cytotoxic antibody screen

Procedure: - measures degree of reactivity of tested serum in terms of - % of cells killed - average strength of serum reactivity in terms of graded reactions - specificity of serum reactivity in terms of the HLA antigens shared in common by those cells killed by the serum Method: - complement Dependent Lymphocytotoxicity and ELISA Clinical significance: - identifies patient as an immune responder, potentially capable of transplantation rejection - specificity of reactivity indicates antigen(s) to be avoided in any prospective donor or indicates the development of response to donor antigens mismatched to recipient at time of transplantation.

General

tissue typing serology

References

  1. Tissue Typing, Cytotoxic Antibody Screen (PRA) http://www.pathology.med.umich.edu/apps/handbook/details.php?testID=353
  2. LOINC :accession 31337-9
  3. CPT :accession 86807