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cytotoxic & regulatory T-cell molecule; class-I MHC-restricted T-cell-associated molecule; CD355 (CRTAM)
Function:
- interaction with CADM1 promotes
a) NK cell cytotoxicity & IFN-gamma secretion by CD8+ cells in vitro
b) NK cell-mediated rejection of tumors expressing CADM3 in vivo
- interacts with CADM1
Structure:
- belongs to the nectin family
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- in the immune system, expression is restricted to activated class-1 MHC-restricted cells, including NKT & CD8 cells
- strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, & in Purkinje neurons in cerebellum
- expressed at much lower levels in testis, ovary, colon, lung & lymphoid tissues
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
Properties
SIZE: entity length = 393 aa
MW = 45 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-17}
immunoglobulin superfamily domain {18-114}
MOTIF: N-glycosylation site {N21}
cysteine residue {C38}
MODIFICATION: cysteine residue {C98}
N-glycosylation site {N87}
cysteine residue {C98}
MODIFICATION: cysteine residue {C38}
immunoglobulin superfamily domain {118-210}
MOTIF: cysteine residue {C141}
MODIFICATION: cysteine residue {C196}
N-glycosylation site {N178}
cysteine residue {C196}
MODIFICATION: cysteine residue {C141}
transmembrane domain {288-308}
Database Correlations
OMIM 612597
UniProt O95727
PFAM correlations
Entrez Gene 56253
Kegg hsa:56253
References
- Kennedy J, Vicari AP, Saylor V, Zurawski SM, Copeland NG,
Gilbert DJ, Jenkins NA, Zlotnik A.
A molecular analysis of NKT cells: identification of a class-I
restricted T cell-associated molecule (CRTAM).
J Leukoc Biol. 2000 May;67(5):725-34.
PMID: 10811014
- Galibert L, Diemer GS, Liu Z, Johnson RS, Smith JL, Walzer T,
Comeau MR, Rauch CT, Wolfson MF, Sorensen RA, Van der Vuurst
de Vries AR, Branstetter DG, Koelling RM, Scholler J,
Fanslow WC, Baum PR, Derry JM, Yan W.
Nectin-like protein 2 defines a subset of T-cell zone dendritic
cells and is a ligand for class-I restricted T-cell associated
molecule.
J Biol Chem. 2005 Mar 21; [Epub ahead of print]
PMID: 15781451
- Boles KS, Barchet W, Diacovo T, Cella M, Colonna M.
The tumor suppressor TSLC1/NECL-2 triggers NK cell and CD8+
T cell responses through the cell surface receptor CRTAM.
Blood. 2005 Apr 5; [Epub ahead of print]
PMID: 15811952
- UniProt :accession O95727