Search
cytosolic purine 5'-nucleotidase (5'-nucleotidase cytosolic 2, NT5C2, NT5B, NT5CP, PNT5)
Function:
1) role in the maintenance of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases
2) preferentially hydrolyzes inosine 5-prime-monophosphate (IMP) & other purine nucleotides
3) allosterically activated by ATP
5'-ribonucleotide + H2O ribonucleoside + phosphate
Compartment: cytoplasm
Pathology:
1) defects or misregulation may be related to the urate production in hyperuricemia & gout
General
enzyme
Properties
SIZE: MW = 65 kD
entity length = 561 aa
COMPARTMENT: cytoplasm
MOTIF: active site
acidic region {549-561}
MOTIF: acidic residue (SEVERAL)
Database Correlations
OMIM 600417
UniProt P49902
Pfam PF05761
ENZYME 3.1.3.5
References
UniProt :accession P49902