cytosolic acyl coenzyme A thioester hydrolase; acyl-CoA thioesterase 7; brain acyl-CoA hydrolase; CTE-IIa; CTE-II; long chain acyl-CoA thioester hydrolase (ACOT7, BACH)

Function: - acyl-CoA thioesterases are a group of enzymes that catalyze hydrolysis of acyl-CoAs to the free fatty acid & coenzyme A, thus may regulate intracellular levels of acyl-CoAs, free fatty acids & coenzyme A - may a role in brain - may play a regulatory role by modulating the cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as thesubstrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis - broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18 - maximal activity toward palmitoyl-CoA - homodimer (probable) Structure: - contains 2 acyl coenzyme A hydrolase domains Compartment: - isoform 1: mitochondria - isoform 4: cytoplasm - isoform 5: mitochondria - isoform 6: cytoplasm Alternative splicing: named isoforms=6 Expression: - isoform 4 is expressed exclusively in brain

Properties

SIZE: entity length = 380 aa MW = 42 kD COMPARTMENT: mitochondria cytoplasm MOTIF: Acyl coenzyme A hydrolase 1 {68-151} active site Acyl coenzyme A hydrolase 2 {242-319}

Database Correlations

OMIM 602587 UniProt O00154 Pfam PF03061 Entrez Gene 11332 Kegg hsa:11332 ENZYME 3.1.2.2

References

UniProt :accession O00154