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cytosolic 5'-nucleotidase 1A (cN1A, NT5C1A)
Function:
1) dephosphorylates the 5' & 2'(3')-phosphates of deoxyribonucleotides
2) broad substrate specificity
3) regulation of adenosine levels in heart during ischemia & hypoxia
4) activated by ADP
Structure: belongs to the 5'-nucleotidase type 3 family
Compartment: cytoplasm
Expression:
- expressed in skeletal muscle > heart, brain, kidney, pancreas
Pathology:
- NT5C1A autoantibody in patients with inclusion body myositis
General
5'nucleotidase (5'-ribonucleotide phosphohydrolase)
Properties
SIZE: MW = 41 kD
entity length = 368 aa
COMPARTMENT: cytoplasm
lysosome
plasma membrane
MOTIF: aspartate residue {D211}
Database Correlations
OMIM 610525
UniProt Q9BXI3
Pfam PF06189
Entrez Gene 84618
Kegg hsa:84618
ENZYME 3.1.3.5
References
- UniProt :accession Q9BXI3