Search
cytoskeleton-associated protein 5 (colonic & hepatic tumor over-expressed protein, Ch-TOG protein, CKAP5, KIAA0097)
Function:
- plays a major role in organizing spindle poles
- interacts with TACC1
Structure:
- belongs to the TOG/XMAP215 family
- contains 9 HEAT repeats
Expression:
- expressed in skeletal muscle, brain, heart, placenta, lung, liver, kidney, pancrea
Pathology: over-expressed in hepatomas & colonic tumors
General
cytoskeletal protein
Properties
SIZE: MW = 226 kD
entity length = 2032 aa
COMPARTMENT: cytoplasm
MOTIF: HEAT repeat {160-197}
HEAT repeat {357-394}
HEAT repeat {435-472}
HEAT repeat {751-788}
Ser phosphorylation site {S816}
HEAT repeat {937-974}
HEAT repeat {1014-1051}
HEAT repeat {1285-1322}
HEAT repeat {1324-1357}
HEAT repeat {1362-1399}
Database Correlations
UniProt Q14008
Pfam PF02985
References
UniProt :accession Q14008